GHK-Cu
$35.00 – $55.00Price range: $35.00 through $55.00
GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine (glycyl-L-histidyl-L-lysine) complexed with a copper(II) ion. Found in human plasma, saliva, and urine with concentrations that decline significantly with age, this peptide was first isolated from human plasma in 1973. GHK-Cu functions as a signal and carrier peptide, exerting pleiotropic effects by modulating the expression of thousands of human genes and influencing multiple cellular pathways involved in tissue remodeling and regeneration. Its primary mechanism involves stimulating collagen, elastin, proteoglycan, and glycosaminoglycan synthesis in fibroblasts while activating lysyl oxidase to improve tissue tensile strength. The peptide also suppresses pro-inflammatory cytokines (TNF-α, IL-6) and demonstrates potent antioxidant activity. Clinically, GHK-Cu is widely utilized in skincare and hair products for its ability to improve skin firmness, reduce fine lines and wrinkles, accelerate wound healing, and support overall skin and hair regeneration.
Buy GHK-Cu — the Copper Tripeptide Powering Regenerative Research
GHK-Cu (Glycyl-L-Histidyl-L-Lysine copper complex), also known as Copper Tripeptide-1, is a naturally occurring tripeptide first isolated from human plasma in 1973. Its high affinity for copper ions (Cu²⁺) and its profound influence on gene expression have made it a cornerstone compound in tissue remodeling, wound healing, and anti-aging research.
Unlike simple peptides, GHK-Cu functions as a gene expression modulator, influencing over 31% of human genes at just 1 micromolar concentration—upregulating 2,686 genes and downregulating 2,616 genes. This broad-spectrum activity underpins its remarkable regenerative profile. GHK-Cu stimulates collagen I, III, and IV synthesis in fibroblasts, enhances glycosaminoglycan production, and promotes angiogenesis and fibroblast migration. It also regulates matrix metalloproteinases (MMPs), clearing damaged collagen debris while promoting new matrix synthesis. Emerging research highlights its anti-inflammatory and antioxidant effects via the JAK/STAT pathway, plus mitochondrial preservation through DAF-16/SKN-1 activation.
Key Research Applications:
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Wound healing and tissue regeneration studies
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Collagen synthesis and extracellular matrix (ECM) remodeling
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Metal-chelation and copper transport research
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Gene expression modulation and antioxidant signaling
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Skin and hair follicle biology investigations
When you Buy GHK-Cu from our catalog, you receive a high-purity, lyophilized powder (50mg or 100mg options) with ≥99% HPLC purity, verified by third-party COAs. Each vial is supplied as a distinctive blue freeze-dried powder for reconstitution, tested for endotoxins and heavy metals.
Important: This product is intended strictly for laboratory research use only. It is not for human or veterinary use, and not for diagnostic, cosmetic, or therapeutic applications.
Ready to advance your regenerative research? Buy GHK-Cu today and join laboratories worldwide relying on verified purity, batch-level transparency, and U.S.-made quality.
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