Pinealon (Tripeptide EDR)

Product Overview

Pinealon (also referred to as Glu-Asp-Arg or T-33 peptide) is a synthetic, short-chain tripeptide composed of three amino acids: Glutamic Acid, Aspartic Acid, and Arginine. Classified under MeSH Supplementary Concept C570174, this endogenous peptide analog has garnered attention in the fields of neurology and gerontology for its ability to modulate cellular viability in brain tissue .

Unlike polypeptide complexes, Pinealon is a low-molecular-weight bioregulator designed to cross the blood-brain barrier effectively. It is strictly intended for in vitro and in vivo research purposes, specifically for studying the mechanisms of oxidative stress, neuronal apoptosis, and cognitive decline.

CAS Number: 175175-23-2
Molecular Formula: C15H26N6O8
Molecular Weight: 418.40 g/mol
Sequence: H-Glu-Asp-Arg-OH (EDR)
Purity: >99%

Key Mechanisms of Action (Research Summary)

1. Suppression of Reactive Oxygen Species (ROS)

Research indicates that Pinealon prevents the accumulation of Reactive Oxygen Species (ROS) in cerebellar granule cells. In studies involving ouabain-induced oxidative stress, Pinealon demonstrated a dose-dependent ability to neutralize free radicals, thereby increasing cell viability .

2. Inhibition of ERK 1/2 Activation

Pinealon suppresses the activation of ERK 1/2 (Extracellular signal-Regulated Kinase) pathways. This mechanism is particularly relevant in models of homocysteine-induced neurotoxicity, where Pinealon treatment (10 nM) effectively inhibited pathological signaling cascades .

3. Neuroprotection & Cognitive Support

Pinealon stimulates the functional activity of the main cellular elements of brain tissue while reducing spontaneous cell death. A 2026 short-term performance assay highlighted that Pinealon showed a “trend toward improved working memory without detectable adverse effects” in preclinical models .

4. Anabolic & Geroprotective Activity

Clinical observations suggest that Pinealon exhibits anabolic effects, improving CNS activity and metabolic function. It is categorized as a geroprotector (anti-aging) of the anabolic, neuroprotective type, helping to regulate biological age markers in research models of chronic polymorbidity .

Technical Specifications & Storage

• Physical Form: Lyophilized powder

• Solubility: Soluble in water (H2O : 40 mg/mL, 95.60 mM). Requires ultrasonic warming for optimal dissolution .

• Storage Conditions:

  • Lyophilized: -20°C (Sealed storage, away from moisture).

  • In solution: Aliquot and store at -80°C for up to 6 months. Avoid repeated freeze-thaw cycles.

• Stability: Stable for 1 month at -20°C once reconstituted.

Product Applications

This product is designed for laboratory research use only. Key research areas include:

• Neuroscience: Protection of neurons from hyperhomocysteinemia.

• Aging Research: Studying the biological mechanisms of senescence and cellular vitality.

• Cognitive Science: Evaluation of working memory and skill retention in animal models.

• Molecular Biology: Signaling pathway analysis (ERK, ROS pathways).

Why Choose This Pinealon Peptide?

• High Purity (99.34%+): Validated via HPLC and Mass Spectrometry .

• Precision Dosing: Available in research quantities (5mg to 100mg) to suit various study designs.

• Safety Profile: Studies indicate no effect on chromatin condensation, suggesting a safe profile at the nuclear genetic level .

Disclaimer:

This product is supplied for research and development use only. It is not for human consumption, clinical use, or therapeutic use. This product is not a drug, dietary supplement, or cosmetic. The statements made herein have not been evaluated by the FDA or EMA. Researchers must comply with all local and federal laws.